Recombinant Murine R-Spondin-1 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 315-32 Descripcion R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant Murine R-Spondin-1 is a 27.1 kDa protein consisting of 245 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions. Source: CHO cells Synonyms: Roof plate-specific Spondin-1, RSPO1 AA Sequence: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCQEGLYL HKGRCYPACP EGSTAANSTM ECGSPAQCEM SEWSPWGPCS KKRKLCGFRK GSEERTRRVL HAPGGDHTTC SDTKETRKCT VRRTPCPEGQ KRRKGGQGRR ENANRHPARK NSKEPGSNSR RHKGQQQPQP GTTGPLTSVG PTWAQ Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. Calculated Molecular Weight: 27 kDa Accession Number: Q9Z132 Gene ID: 192199 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Cancer Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Yen, Y Titulo Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response. Citar Nature Communications; 12(1) pg7297 PudMed id 34911954 Primer autor Sufi, J Titulo Multiplexed single-cell analysis of organoid signaling networks Citar Nature Protocols; 16(10) pg4897-4918 PudMed id 34497385 Primer autor Fazilaty, H Titulo Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage. Citar Cell Reports; 36(5) pg109484 PudMed id 34348153
