Recombinant Murine RELMβ 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 450-26B Descripcion RELMβ (Resistin-like molecule β/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokines, resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond. Source: E.coli Synonyms: Resistin-like β, Cysteine-rich secreted protein FIZZ2 AA Sequence (monomer): MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 18 kDa Accession Number: Q99P86 Gene ID: 57263 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Parasite, Pig Intestinal Worm References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation Immune System Inflammation product.subtitle.recentcitations Primer autor LeMessurier, K S Titulo Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta. Citar Scientific Reports; 8(1) pg7061 PudMed id 29728628 Primer autor Steinbrecher, K A Titulo Murine guanylate cyclase C regulates colonic injury and inflammation. Citar Journal of immunology (Baltimore, Md. : 1950); 186(12) pg7205-14 PudMed id 21555532 Primer autor Herbert, D R Titulo Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. Citar The Journal of Experimental Medicine; 206(13) pg2947-57 PudMed id 19995957