Recombinant Human BMP-4 (E.coli derived) 0 리뷰Submit a Review 제품 상세 카다로그 번호 120-05ET 제품 설명 Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Source: E.coli Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4 AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 23.9 kDa Accession Number: P12644 Gene ID: 652 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Pig, Rat References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations 제 1 저자 Jacobo Lopez, A 주제 Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells. 인용 Cell Proliferation; 55(4) pge13198 PubMed ID 35165951 제 1 저자 Aykul, S 주제 BMP-4 Extraction from Extracellular Matrix and Analysis of Heparin-Binding Properties. 인용 Molecular Biotechnology; 64(2) pg156-170 PubMed ID 34550550 제 1 저자 Frey, P 주제 SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer. 인용 Oncogene; 41(6) pg824-837 PubMed ID 34857888