Recombinant Human E-Selectin 0 리뷰Submit a Review 제품 상세 카다로그 번호 150-15 제품 설명 Selectins are a family of calcium-dependent type 1 transmembrane proteins. Endothelial (E)-selectin is a heavily glycosylated transmembrane protein expressed by activated endothelial cells in microvascular linings. E-selectin, along with P-selectin and L-selectin, initiate recruitment of circulating leukocytes from blood to sites of inflammation in the vascular lining through interaction with specific cell surface-associated carbohydrate determinants. E-selectin consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain. Recombinant Human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions. Source: CHO cells Synonyms: Endothelial leukocyte adhesion molecule 1 (ELAM1), CD62E, SELE AA Sequence: WSYNTSTEAM TYDEASAYCQ QRYTHLVAIQ NKEEIEYLNS ILSYSPSYYW IGIRKVNNVW VWVGTQKPLT EEAKNWAPGE PNNRQKDEDC VEIYIKREKD VGMWNDERCS KKKLALCYTA ACTNTSCSGH GECVETINNY TCKCDPGFSG LKCEQIVNCT ALESPEHGSL VCSHPLGNFS YNSSCSISCD RGYLPSSMET MQCMSSGEWS APIPACNVVE CDAVTNPANG FVECFQNPGS FPWNTTCTFD CEEGFELMGA QSLQCTSSGN WDNEKPTCKA VTCRAVRQPQ NGSVRCSHSP AGEFTFKSSC NFTCEEGFML QGPAQVECTT QGQWTQQIPV CEAFQCTALS NPERGYMNCL PSASGSFRYG SSCEFSCEQG FVLKGSKRLQ CGPTGEWDNE KPTCEAVRCD AVHQPPKGLV RCAHSPIGEF TYKSSCAFSC EEGFELHGST QLECTSQGQW TEEVPSCQVV KCSSLAVPGK INMSCSGEPV FGTVCKFACP EGWTLNGSAA RTCGATGHWS GLLPTCEAPT ESNIP Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line. Calculated Molecular Weight: 58.6 kDa Accession Number: P16581 Gene ID: 6401 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation product.subtitle.recentcitations 제 1 저자 Puan, K J 주제 FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression 인용 Communications Biology; 4(1) pg832 PubMed ID 34215830 제 1 저자 Song, K H 주제 Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation. 인용 Scientific Reports; 7(1) pg11533 PubMed ID 28912435 제 1 저자 Lim, C H 주제 Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo. 인용 Scientific Reports; 7(1) pg11201 PubMed ID 28894159
