Recombinant Human GDF-2 0 리뷰Submit a Review 제품 상세 카다로그 번호 120-07 제품 설명 GDF-2 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in non-parenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor, and has been implicated in a number of physiologic events including the regulation of the hepatic reticuloendothelial system, glucose homeostasis, iron homeostasis, and the inhibition of angiogenesis. Recombinant Human GDF-2 is a 24.1 kDa disulfide-linked homodimeric protein consisting of two 110 amino acid polypeptide chains. Source: CHO cells Synonyms: Growth/Differentiation Factor-2, BMP-9 AA Sequence (monomer): SAGAGSHCQK TSLRVNFEDI GWDSWIIAPKE YEAYECKGGC FFPLADDVTPTK HAIVQTLVHL KFPTKVGKAC CVPTKLSPIS VLYKDDMGVP TLKYHYEGMS VAECGCR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml. Calculated Molecular Weight: 24.1 kDa Accession Number: Q9UK05 Gene ID: 2658 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations 제 1 저자 Abdullah, A 주제 Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling 인용 Scientific Reports; 11(1) pg8585 PubMed ID 33883596 제 1 저자 Pous, L 주제 Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. 인용 Nature Communications; 11(1) pg630 PubMed ID 32005867 제 1 저자 Dufton, N P 주제 Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. 인용 Nature Communications; 8(1) pg895 PubMed ID 29026072
