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Neurotrophins

Recombinant Human NT-4

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제품 상세

카다로그 번호 450-04
제품 설명
Recombinant Human NT-4

NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle.  NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons.  Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)

AA Sequence (monomer): GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 28.1 kDa

Accession Number: P34130

Gene ID: 4909

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

제 1 저자
Zhu, Y
주제
Deep learning-based predictive identification of neural stem cell differentiation
인용
Nature Communications; 12(1) pg2614
PubMed ID
제 1 저자
Sun, X
주제
Functionally Distinct Neuronal Ensembles within the Memory Engram.
인용
Cell; 181(2) pg410-423.e17
PubMed ID
제 1 저자
Vandewauw, I
주제
A TRP channel trio mediates acute noxious heat sensing.
인용
Nature; 555(7698) pg662-666
PubMed ID