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Chemokines

Recombinant Human PF-4 (CXCL4)

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제품 상세

카다로그 번호 300-16
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Recombinant Human PF-4 (CXCL4)

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Source: E.coli

Synonyms: Platelet Factor-4, CXCL4, Oncostatin A, Ironplact

AA Sequence: EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P02776

Gene ID: 5196

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

제 1 저자
Matsumoto, K
주제
Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis.
인용
Scientific Reports; 11(1) pg222
PubMed ID
제 1 저자
Carvalheiro, T
주제
Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis.
인용
Arthritis & rheumatology (Hoboken, N.J.); 71(10) pg1711-1722
PubMed ID
제 1 저자
Lee, A W
주제
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
인용
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed ID