Recombinant Murine GDF-5 (BMP-14/CDMP-1) 0 리뷰Submit a Review 제품 상세 카다로그 번호 315-24 제품 설명 GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino acid polypeptide chains (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 348 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. Source: E.coli Synonyms: Growth/Differentiation Factor-5, BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) AA Sequence (monomer): APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 1.0-2.0 µg/ml. Calculated Molecular Weight: 27 kDa Accession Number: P43027 Gene ID: 14563 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cell Culture Immune System Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations 제 1 저자 Li, X 주제 GDF-5 induces epidermal stem cell migration via RhoA-MMP9 signalling. 인용 Journal of Cellular and Molecular Medicine; 25(4) pg1939-1948 PubMed ID 33369147