Recombinant Human Epigen 0 ReviewsSubmit a Review Product Details Catalog Number: 100-51 Description: Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, and heart, as well as in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant Human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF-homologous portion of the Epigen precursor. Source: E.coli Synonyms: EPG, Epithelial mitogen AA Sequence: AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml. Calculated Molecular Weight: 7.9 kDa Accession Number: Q6UW88 Gene ID: 255324 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Inflammation Stem Cells & Differentiation Recent Citations First Author Lindzen, M Title Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53 Citation Oncogene; 40(21) pg3665-3679 PubMed ID 33941851 First Author Ho, J Title Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Citation Nature Communications; 10(1) pg2297 PubMed ID 31127085
