Recombinant Human FGF-8a 0 ReviewsSubmit a Review Product Details Catalog Number: 100-25A Description: FGF-8 is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. The human and murine FGF-8a and FGF-8b are identical, unlike human and mouse FGF-8e and FGF-8f, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. CHO cell-derived Recombinant Human FGF-8a is a 21.2 kDa protein consisting of 182 amino acid residues. Source: CHO cells Synonyms: Fibroblast Growth Factor-8, FGF-8a, AIGF, HBGF-8 AA Sequence: QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using balb/c 3T3 cells. Calculated Molecular Weight: 21.2 kDa Accession Number: P55075 Gene ID: 2253 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Nakajima, T Title Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Citation Nature Communications; 12(1) pg5012 PubMed ID 34408142 First Author Zhang, K Title UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model. Citation Neuron; 109(12) pg1949-1962.e6 PubMed ID 33991504 First Author Truvé, K Title Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder Citation Translational Psychiatry; 10(1) pg390 PubMed ID 33168801
