Recombinant Human NT-3 2 ReviewsSubmit a Review Product Details Catalog Number: 450-03 Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Source: E.coli Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 27.2 kDa Accession Number: P20783 Gene ID: 4908 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Chicken, Cow, Dog, Frog, Hamster, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation Recent Citations First Author Pantazis, C B Title A reference human induced pluripotent stem cell line for large-scale collaborative studies. Citation Cell Stem Cell; 29(12) pg1685-1702.e22 PubMed ID 36459969 First Author Kaluscha, S Title Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation. Citation Nature Genetics; 54(12) pg1895-1906 PubMed ID 36471082 First Author Mesci, P Title SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. Citation PLoS Biology; 20(11) pge3001845 PubMed ID 36327326 Product Reviews Existing reviews I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 21/08/2020 × I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 21/08/2020 Close Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 26/08/2020 × Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 26/08/2020 Close
