Recombinant Human Pleiotrophin 0 ReviewsSubmit a Review Product Details Catalog Number: 450-15 Description: Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds. Source: E.coli Synonyms: PTN, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1) AA Sequence: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 15.4 kDa Accession Number: P21246 Gene ID: 5764 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Chicken, Hamster, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation Recent Citations First Author Notaras, M Title Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids. Citation Molecular Psychiatry; 27(3) pg1416-1434 PubMed ID 34789849 First Author Arnold, N Title A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Citation Nature Communications; 10(1) pg5183 PubMed ID 31729368 First Author Lampropoulou, E Title Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. Citation Scientific Reports; 8(1) pg5893 PubMed ID 29651006
