Recombinant Murine Eotaxin (CCL11) 0 ReviewsSubmit a Review Product Details Catalog Number: 250-01 Description: Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: CCL11 AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Murine Eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 10-100 ng/ml. Calculated Molecular Weight: 8.4 kDa Accession Number: P48298 Gene ID: 20292 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing Recent Citations First Author Felton, J M Title Aiolos regulates eosinophil migration into tissues Citation Mucosal Immunology; 14(6) pg1271-1281 PubMed ID 34341502 First Author Patial, S Title Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs. Citation Scientific Reports; 11(1) pg15465 PubMed ID 34326406 First Author Dileepan, M Title Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A. Citation Journal of Immunology; 204(3) pg682-693 PubMed ID 31871023
