Recombinant Murine LIGHT 0 ReviewsSubmit a Review Product Details Catalog Number: 315-12 Description: LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain. Source: E.coli Synonyms: TNFSF14, HVEM-L AA Sequence: MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its cytotoxic effecton HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-γ. Calculated Molecular Weight: 20.1 kDa Accession Number: Q9QYH9 Gene ID: 50930 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Cancer Immune System Inflammation TNF Superfamily Recent Citations First Author Waldemer-Streyer, R J Title Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration. Citation Cell death & disease; 6 pge2026 PubMed ID 26720335 First Author Pontejo, S M Title Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors. Citation The Journal of Biological Chemistry; 290(26) pg15973-84 PubMed ID 25940088 First Author Fan, K Title Preparation and characterization of a monoclonal antibody against the protein LIGHT. Citation Hybridoma (2005); 24(6) pg309-13 PubMed ID 16332198
