Recombinant Murine MCP-5 (CCL12)

Product Details

Catalog Number: 250-04

Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine MCP-5 is a 9.3 kDa protein containing 82 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-5, CCL12

AA Sequence: GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.

Calculated Molecular Weight: 9.3 kDa

Accession Number: Q62401

Gene ID: 20293

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Cross Reactivity Cited in References:

Bacteria, Human, Mouse

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

Recent Citations

First Author

Hansell, C A

Title

The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.

Citation

Journal of immunology (Baltimore, Md. : 1950); 201(8) pg2510-2519

PubMed ID

30158126

First Author

Yagawa, Y

Title

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Citation

Scientific Reports; 7(1) pg15996

PubMed ID

29167448

First Author

Singh, K

Title

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Citation

Scientific Reports; 7(1) pg4267

PubMed ID

28655871

Chemokines