Recombinant Murine Midkine 0 ReviewsSubmit a Review Product Details Catalog Number: 315-25 Description: Midkine (MK) and its functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant Murine Midkine is a 13.3 kDa protein containing 120 amino acid residues including five intra-molecular disulfide bonds. Source: E.coli Synonyms: MK, NEGF-2 AA Sequence: VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKSK TKAKKGKGKD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml. Calculated Molecular Weight: 13.3 kDa Accession Number: P12025 Gene ID: 17242 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Neurobiology Stem Cells & Differentiation Recent Citations First Author Weckbach, L T Title Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. Citation The Journal of Experimental Medicine; 216(2) pg350-368 PubMed ID 30647120
