Recombinant Rat CNTF 0 ReviewsSubmit a Review Product Details Catalog Number: 450-50 Description: CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Rat CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion. Source: E.coli Synonyms: Ciliary Neurotrophic Factor AA Sequence: AFAEQTPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNINLD SVDGVPVAST DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHT LMLQVSAFAY QLEELMVLLE QKIPENEADG MPATVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRVISS HQMGISALES HYGAKDKQM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml. Calculated Molecular Weight: 22.7 kDa Accession Number: P20294 Gene ID: 25707 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Frog, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Hensel, N Title Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy. Citation Proceedings of the National Academy of Sciences of the United States of America; 118(18) PubMed ID 33931501 First Author Passaro, A P Title Development of an objective index, neural activity score (NAS), reveals neural network ontogeny and treatment effects on microelectrode arrays Citation Scientific Reports; 11(1) pg9110 PubMed ID 33907294 First Author Siebert, J R Title Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans. Citation Journal of Neuroscience Research; 99(4) pg1009-1023 PubMed ID 33453083
