Anti-Human/Mouse CD44 SAFIRE Purified (Clone#: IM7) Produktdetails Katalognummer: 06511-25 Beschreibung: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes. Source: Isotype: Rat IgG2b, kappa; Clone#: IM7 Note: Product supplied by BiogemsSAFIRE (Sodium Azide Free Immensely Reduced Endotoxin) products are BioGems’ line of functional antibodies that can be used for activation, blocking, and neutralization studies. They are manufactured carrier and sodium azide free, with immensely reduced endotoxin levels of 0.01 EU/ug or lower for in vivo and in vitro applications. crossreactivity: Human, Mouse Research Interest Immune System Product Line Country Of Origin: USA Not for human use.
