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Monoklonale Antikörper


Anti-Mouse ROR gamma Purified (Clone#: RORg2)


Katalognummer: 77612-20
The Retinoid-related orphan receptor gamma is in the nuclear hormone receptor of transcription factors and is produced as two isoforms, gamma1 and gamma2. The isoforms differ through the n-terminus. It is reported that Th17 cells utilize this receptor to specify their differentiation and lineage-specific function. The transcription factor is essential for lymphoid organogenesis, in particular lymph nodes and Peyer's patches, but not the spleen. It also plays a role in inhibiting apoptosis of undifferentiated T cells and promoting their differentiation into Th17 cells, possibly by down regulating the expression of Fas ligand and IL2, respectively.

Source: Isotype: Armenian hamster IgG; Clone#: RORg2


Product supplied by Biogems

crossreactivity: Research Interest

Country Of Origin: USA

Not for human use.