Human GDF-15/MIC-1 (Cell Culture derived) 1 ReviewsSubmit a Review Product Details Catalogue Number: 120-28 Description: GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Human GDF-15/MIC-1 is 24.6 kDa. Note: Once inventory is depleted, this protein will be replaced with (PeproTech catalog# 120-28C) Source: Cell Culture Synonyms: Growth/Differentiation Factor-15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor AA Sequence (monomer): ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osetoblast cells. The expected ED50 for this effect is 1.0-3.0 μg/ml. Calculated Molecular Weight: 24.6 kDa Accession Number: Q99988 Gene ID: 9518 Note: 100μg is the largest vial size for this product. Larger sizes supplied as multiple 100μg vials. crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cell Culture Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Zhang, Y Title Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy. Citation Scientific Reports; 5 pg11235 PubMed Id 26057572 First Author Tsui, K Title Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells. Citation Scientific Reports; 5 pg12870 PubMed Id 26249737 First Author Tanno, T Title Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells. Citation Blood; 123(5) pg725-33 PubMed Id 24345755 product.subtitle.productreviews Existing reviews OK for some applications Some batches had TGFb levels that were too high for our applications From: Ling | Date: 08.07.2020 × OK for some applications Some batches had TGFb levels that were too high for our applications From: Ling | Date: 08.07.2020 Close
