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Recombinant Human Amphiregulin

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Product Details

Catalogue Number: 100-55B
Description:
Recombinant Human Amphiregulin

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Source: E.coli

Synonyms: AR, AREG, Colorectum cell-derived growth factor (CRDGF)

AA Sequence: SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.

Calculated Molecular Weight: 11.3 kDa

Accession Number: P15514

Gene ID: 374

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hara, T
Title
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Citation
Cancer Cell; 39(6) pg779-792.e11
PubMed Id
First Author
Ghosh, S
Title
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Citation
Cell Reports; 35(8) pg109181
PubMed Id
First Author
Lindzen, M
Title
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53
Citation
Oncogene; 40(21) pg3665-3679
PubMed Id