Andere Proteine

Recombinant Human ApoA-I

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Product Details

Catalogue Number: 350-11
Description:

ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high density lipoprotein (HDL) particle.  ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol.  This ApoA-I ability enables HDL to remove excess peripheral cholesterol, and return it to the liver for recycling and excretion.  This process, called reverse cholesterol transport, is thought to inhibit atherogenesis.  For this reason, HDL is also known as the "good cholesterol".  The therapeutic potential of ApoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of ApoA-I (called ApoA-I Milano).  The availability of recombinant normal ApoA-I should facilitate further investigation into the potential usefulness of ApoA-I in preventing atherosclerotic vascular diseases.  Recombinant Human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

Source: E.coli

Synonyms: Apolipoprotein A-I

AA Sequence: MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ

Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 28.2 kDa

Accession Number: P02647

Gene ID: 335

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
van der Westhuyzen, D R
Title
Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.
Citation
The Journal of Biological Chemistry; 280(43) pg35890-5
PubMed Id
First Author
Burgess, E J
Title
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
Citation
Journal of immunology (Baltimore, Md. : 1950); 201(8) pg2377-2384
PubMed Id
First Author
Cai, H
Title
Serum amyloid A induces monocyte tissue factor.
Citation
Journal of immunology (Baltimore, Md. : 1950); 178(3) pg1852-60
PubMed Id