Neurotrophine

Recombinant Human Artemin

Product Details

Catalogue Number: 450-17
Description:

Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, artemin, neurturin and persephin. These proteins belong to the cysteine knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, persephin and neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRα (α1-α4) receptors. Artemin prefers the receptor GFRα3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia, such as sympathetic, neural crest and placodally-derived sensory neurons, and dopaminergic midbrain neurons. The functional human artemin ligand is a disulfide-linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine-knot configuration. Recombinant Human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits.

Source: E.coli

Synonyms: ART, ARTN, Enovin, Neublastin

AA Sequence (monomer): AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.

Calculated Molecular Weight: 24.2 kDa

Accession Number: Q5T4W7

Gene ID: 9048

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hedstrom, K L
Title
Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(6) pg2325-30
PubMed Id
First Author
Banerjee, A
Title
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Citation
PLoS ONE; 7(11) pge50098
PubMed Id
First Author
Schmutzler, B S
Title
Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization.
Citation
Molecular Pain; 7 pg22
PubMed Id