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Recombinant Human Betacellulin

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Product Details

Catalogue Number: 100-50
Description:

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant Human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino acid residues, which comprises the mature EGF-homologous portion of the Betacellulin protein.

Source: E.coli

Synonyms: BTC

AA Sequence: DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.

Calculated Molecular Weight: 9 kDa

Accession Number: P35070

Gene ID: 685

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Shee, K
Title
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Citation
The Journal of Experimental Medicine; 215(3) pg895-910
PubMed Id
First Author
Freed, D M
Title
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Citation
Cell; 171(3) pg683-695.e18
PubMed Id
First Author
Zhang, D
Title
Betacellulin Regulates the Proliferation and Differentiation of Retinal Progenitor Cells in Vitro
Citation
Journal of Cellular and Molecular Medicine; 22 (1), 330-345
PubMed Id