Recombinant Human BMP-4 (E.coli derived) 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-05ET Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Source: E.coli Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4 AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 23.9 kDa Accession Number: P12644 Gene ID: 652 Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Carvalho, D Title ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma. Citation Communications Biology; 2:156 PubMed Id 31098401 First Author Nanki, K Title Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Citation Cell; 174(4) pg856-869.e17 PubMed Id 30096312 First Author Vanhove, J Title H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro. Citation Stem Cell Reports; 7(2) pg192-206 PubMed Id 27477635
