Chemokine

Recombinant Human Eotaxin (CCL11)

Product Details

Catalogue Number: 300-21
Description:

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.

Calculated Molecular Weight: 8.3 kDa

Accession Number: P51671

Gene ID: 6356

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Bonecchi, R
Title
Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils.
Citation
Journal of immunology (Baltimore, Md. : 1950); 162(1) pg474-9
PubMed Id
First Author
Hamada, T
Title
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.
Citation
The Journal of Experimental Medicine; 188(3) pg539-48
PubMed Id
First Author
Sallusto, F
Title
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Citation
The Journal of Experimental Medicine; 187(6) pg875-83
PubMed Id

product.subtitle.productreviews

Existing reviews
Useful for western blot antibody validation
Yielded a clean band at the expected molecular weight (~11kDa).
From:  Anthony | Date:  10.07.2020