Chemokine

Recombinant Human Eotaxin (CCL11)

Product Details

Catalogue Number: 300-21
Description:
Recombinant Human Eotaxin (CCL11)

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.

Calculated Molecular Weight: 8.3 kDa

Accession Number: P51671

Gene ID: 6356

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Bouhaddou, M
Title
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Citation
Cell; 182(3) pg685-712.e19
PubMed Id
First Author
Lee, A W
Title
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Citation
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed Id
First Author
Alenazi, Y
Title
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Citation
Scientific Reports; 8(1) pg6333
PubMed Id

product.subtitle.productreviews

Existing reviews
Useful for western blot antibody validation
Yielded a clean band at the expected molecular weight (~11kDa).
From:  Anthony | Date:  10.07.2020