Recombinant Human Epiregulin 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-04 Description: Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant Human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence. Source: E.coli Synonyms: EREG AA Sequence: MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 5.6 kDa Accession Number: O14944 Gene ID: 2069 crossreactivity: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Gao, B Title BMP7 and EREG Contribute to the Inductive Potential of Dental Mesenchyme. Citation Scientific Reports; 5 pg9903 PubMed Id 25952286 First Author Ho, J Title Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Citation Nature Communications; 10(1) pg2297 PubMed Id 31127085 First Author Choi, N Title Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation. Citation Cell Proliferation; pge12881 PubMed Id 32700456