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Recombinant Human FGF-6

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Product Details

Catalogue Number: 100-30
Description:
Recombinant Human FGF-6

FGF-6 is a secreted, heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant Human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-6, HBGF-6, HST-2

AA Sequence: GTRANNTLLD SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT VTHFLPRI

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 106 units/mg.

Calculated Molecular Weight: 18.7 kDa

Accession Number: P10767

Gene ID: 2251

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Savchenko, E
Title
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Citation
Scientific Reports; 9(1) pg9610
PubMed Id
First Author
Ishihara, J
Title
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Citation
Nature Communications; 9(1) pg2163
PubMed Id
First Author
Shee, K
Title
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Citation
The Journal of Experimental Medicine; 215(3) pg895-910
PubMed Id