Chemokine

Recombinant Human Fractalkine (CX3CL1)

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Product Details

Catalogue Number: 300-31
Description:

Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Fractalkine is, at this time, the only CXC3C chemokine that contains three amino acid residues between the first and second cysteine residues of the chemokine domain. The Fractalkine gene encodes for a 397 amino acid precursor protein containing a 24 amino acid signal sequence, a chemokine domain, and a "mucin-like stalk" sequence, which is followed by the transmembrane domain containing approximately 20 amino acids, and a C-terminal cytoplasmic domain.  The extracellular chemokine domain contains 76 amino acid residues, including the four conserved cysteine residues found in other chemokines. Recombinant Human Fractalkine is an 8.5 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Neurotactin, CX3CL1, FKN

AA Sequence: QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 5.0-10.0 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: P78423

Gene ID: 6376

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Grubman, A
Title
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.
Citation
Stem Cell Reports; 14(6) pg1018-1032
PubMed Id
First Author
Chen, T
Title
Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Citation
Molecular Pain; 6 pg19
PubMed Id
First Author
Ridderstad Wollberg, A
Title
Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(14) pg5409-14
PubMed Id