Recombinant Human I-309 (CCL1) 0 BewertungenSubmit a Review Produktdetails Katalognummer: 300-37 Beschreibung: I-309 is a CC chemokine that signals through the CCR8 receptor. It is secreted by T-lymphocytes, monocytes and mast cells. I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils. Human I-309 is active on murine cells. Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. Source: E.coli Synonyms: CCL1, TCA-3 AA Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P22362 Gene ID: 6346 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Monkey, Mouse References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations Erstautor Galeano Niño, J L Titel Cytotoxic T cells swarm by homotypic chemokine signalling. Literaturstelle eLIFE; 9 PubMed ID 33046212 Erstautor Yasuoka, H Titel Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis Literaturstelle Scientific Reports; 10(1) pg10377 PubMed ID 32587357 Erstautor Lee, A W Titel A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Literaturstelle The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed ID 31167786