Recombinant Human I-309 (CCL1) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-37 Description: I-309 is a CC chemokine that signals through the CCR8 receptor. It is secreted by T-lymphocytes, monocytes and mast cells. I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils. Human I-309 is active on murine cells. Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. Source: E.coli Synonyms: CCL1, TCA-3 AA Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P22362 Gene ID: 6346 crossreactivity: Bacteria, Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Wright, D E Title Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. Citation The Journal of Experimental Medicine; 195(9) pg1145-54 PubMed Id 11994419 First Author Tiffany, H L Title Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. Citation The Journal of Biological Chemistry; 276(26) pg23645-52 PubMed Id 11316806 First Author Barington, L Title Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. Citation The Journal of Biological Chemistry; 291(31) pg16208-20 PubMed Id 27226537
