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Recombinant Human IFN-λ1

Product Details

Catalogue Number: 300-02L
Description:

IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons.  All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14).  Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons.  Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues.

Source: E.coli

Synonyms: IL-29

AA Sequence: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.

Calculated Molecular Weight: 19.8 kDa

Accession Number: Q8IU54

Gene ID: 282618

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sposito, B
Title
The interferon landscape along the respiratory tract impacts the severity of COVID-19.
Citation
Cell; 184(19) pg4953-4968.e16
PubMed Id
First Author
Busnadiego, I
Title
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
Citation
mBio; 11(5)
PubMed Id
First Author
Stanifer, M L
Title
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Citation
Cell Reports; 32(1) pg107863
PubMed Id