Animal-Free Recombinant Human IGF-BP3 0 BewertungenSubmit a Review Produktdetails Katalognummer: AF-100-08 Beschreibung: IGF-BP3 is a 30 kDa, cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Insulin-like Growth, Factor-Binding Protein3, IBP-3, Growth-hormone-dependent binding protein AA Sequence: GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 is ≤ 0.2 μg/ml in the presence of 15 ng/ml of human IGF-II. Calculated Molecular Weight: 28.8 kDa Accession Number: P17936 Gene ID: 3486 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Diabetes/Weight Regulation
