Recombinant Human IL-1α 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-01A Description: IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues. Source: E.coli Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18 kDa Accession Number: P01583 Gene ID: 3552 crossreactivity: Cow, Frog, Human, Human + Mouse, Monkey, Mouse, Pig References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Ren, X Title Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling. Citation Nature Communications; 8(1) pg810 PubMed Id 28993621 First Author Bossi, F Title C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Citation Blood; 113(15) pg3640-8 PubMed Id 19179470 First Author Miyahara, Y Title Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Citation Proceedings of the National Academy of Sciences of the United States of America; 105(40) pg15505-10 PubMed Id 18832156
