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Recombinant Human IL-15

Product Details

Catalogue Number: 200-15
Description:

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.  IL-15 exerts its biological activities primarily on T cells.  It is also essential in the development, survival and activation of NK cells.  Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.  Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.  Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: Interleukin-15, IL-T

AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 12.9 kDa

Accession Number: P40933

Gene ID: 3600

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sancho, D
Title
Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15.
Citation
Blood; 93(3) pg886-96
PubMed Id
First Author
Qin, J Z
Title
Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells.
Citation
Blood; 93(1) pg260-7
PubMed Id
First Author
Imada, K
Title
Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity.
Citation
The Journal of Experimental Medicine; 188(11) pg2067-74
PubMed Id