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Recombinant Human IL-15

Product Details

Catalogue Number: 200-15
Description:
Recombinant Human IL-15

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.  IL-15 exerts its biological activities primarily on T cells.  It is also essential in the development, survival and activation of NK cells.  Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.  Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.  Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: Interleukin-15, IL-T

AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Recombinant Human IL-15 WHO Comparison Graph Recombinant Human IL-15 Biological Activity Graph

Calculated Molecular Weight: 12.9 kDa

Accession Number: P40933

Gene ID: 3600

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wang, W
Title
Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors.
Citation
Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(22) pge2105810
PubMed Id
First Author
Moosmann, C
Title
Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.
Citation
STAR Protocols; 3(1) pg101031
PubMed Id
First Author
Matis, S
Title
LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells.
Citation
Hematological Oncology; 40(1) pg40-47
PubMed Id

product.subtitle.productreviews

Existing reviews
CD8 stimulation culture
When used at 10 ng/mL, it promoted the survival and expansion of human CD8+ T cells. Cells were stimulated with anti-CD3/anti-CD28 for 2 days in the presence of rhIL-15 and then expanded for 6 days in the presence of rhIL-15 alone.
From:  Michael | Date:  08.08.2023