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Recombinant Human IL-19

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Product Details

Catalogue Number: 200-19
Description:


Recombinant Human IL-19

IL-19 belongs to the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine, because it up-regulates IL-6 and TNF-α, and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant Human IL-19 is a 35.8 kDa homodimer of two 154 amino acid chains. In solution, IL-19 exists predominantly as a non-disulfide-linked dimer.

Source: E.coli

Synonyms: Interleukin-19, Melanoma differentiation association like protein

AA Sequence (monomer): MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction.

Calculated Molecular Weight: 35.8 kDa

Accession Number: Q9UHD0

Gene ID: 29949

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zenewicz, L A
Title
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.
Citation
Immunity; 29(6) pg947-57
PubMed Id
First Author
Jordan, W J
Title
Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.
Citation
European Journal of Immunology; 35(5) pg1576-82
PubMed Id