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Recombinant Human IL-1RA

Product Details

Catalogue Number: 200-01RA
Description:

Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein.  It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors.  IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.  Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.  Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Source: E.coli

AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.

Calculated Molecular Weight: 17.2 kDa

Accession Number: P14778

Gene ID: 3554

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Cartmell, T
Title
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 19(4) pg1517-23
PubMed Id
First Author
Bouhaddou, M
Title
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Citation
Cell; 182(3) pg685-712.e19
PubMed Id
First Author
Wang, Q
Title
Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats.
Citation
CNS Neuroscience &Amp; Therapeutics;
PubMed Id