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Recombinant Human IL-22

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Product Details

Catalogue Number: 200-22
Description:

IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26.  Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions.  Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas.  IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.  Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

Source: E.coli

Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18

AA Sequence (monomer): MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1: Determined by its ability to activate STAT following receptor ligand interaction.

Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/ml.

Calculated Molecular Weight: 33.6 kDa

Accession Number: Q9GZX6

Gene ID: 50616

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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Fujii, S
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PGE
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Scientific Reports; 6 pg36795
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Edwards, L A
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Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
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