Wachstumsfaktoren & Zytokine

Recombinant Human IL-23

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 200-23
Description:


Recombinant Human IL-23

IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Source: (BTI-Tn-5B1-4) Hi-5 Insect cells

Synonyms: Interleukin-23

AA Sequence: p19 Subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP

p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-17 secretion by mouse splenocytes.

Calculated Molecular Weight: 53.5 kDa

Accession Number: p19: Q9NPF7 p40: P29460

Gene ID: p19: 51561 p40: 3593

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Malik, S
Title
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Citation
Nature Communications; 8(1) pg815
PubMed Id
First Author
Zhao, M
Title
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Citation
Nature Communications; 9(1) pg583
PubMed Id
First Author
Chen, J
Title
Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.
Citation
Scientific Reports; 7(1) pg17233
PubMed Id