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Recombinant Human IL-31

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Product Details

Catalogue Number: 200-31
Description:

Human IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (also known as gp130-like receptor or IL-31RA) and Oncostatin-M receptor (OSMR). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways. IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

Source: E.coli

Synonyms: Interleukin-31

AA Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce STAT3 activation in human U87 cells.

Calculated Molecular Weight: 15.8 kDa

Accession Number: Q6EBC2

Gene ID: 386653

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Umehara, Y
Title
Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells.
Citation
Scientific Reports; 10(1) pg4360
PubMed Id
First Author
Braz, J M
Title
Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 118(8)
PubMed Id
First Author
Hänel, K H
Title
Control of the Physical and Antimicrobial Skin Barrier by an IL-31-IL-1 Signaling Network.
Citation
Journal of immunology (Baltimore, Md. : 1950); 196(8) pg3233-44
PubMed Id