Animal-Free Recombinant Human IL-33 0 BewertungenSubmit a Review Produktdetails Katalognummer: AF-200-33 Beschreibung: Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-33, IL-1 F11, NF-HEV AA Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. Calculated Molecular Weight: 17.9 kDa Accession Number: O95760 Gene ID: 90865 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation product.subtitle.recentcitations Erstautor Zhou, Q Titel The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis. Literaturstelle Oncogene; 39(7) pg1414-1428 PubMed ID 31659258 Erstautor Malmhäll, C Titel MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level. Literaturstelle ACS Medicinal Chemistry Letters; 17(5):544-546 PubMed ID 31601967 Erstautor Connolly, D J Titel The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. Literaturstelle The Journal of Biological Chemistry; 288(8) pg5616-23 PubMed ID 23319592
