Chemokine

Recombinant Human IL-8 (CXCL8) (77 a.a.)

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Product Details

Catalogue Number: 200-08
Description:

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (CXCL8) (77 a.a.) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues.

Source: E.coli

Synonyms: Interleukin-8, CXCL8, monocyte-derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), NAP-1

AA Sequence: AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0-150.0 ng/ml.

Calculated Molecular Weight: 8.9 kDa

Accession Number: P10145

Gene ID: 3576

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zhang, Y
Title
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Citation
Scientific Reports; 7(1) pg15038
PubMed Id
First Author
Subramanian, B C
Title
The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation.
Citation
The Journal of Cell Biology; 219(10)
PubMed Id
First Author
Su, S
Title
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Citation
Cell; 175(2) pg442-457.e23
PubMed Id