Chemokine

Recombinant Human LAG-1 (CCL4L1)

Product Details

Catalogue Number: 300-58
Description:

LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1β (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor. Recombinant Human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.

Source: E.coli

Synonyms: Lymphocyte Activation Gene-1, CCL4L1, ACT-2, T-cell activiation-2, HC21

AA Sequence: APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract CCR5-transfected cells using a concentration of 0.1-10.0 ng/ml

Calculated Molecular Weight: 7.7 kDa

Accession Number: Q8NHW4

Gene ID: 388372

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lee, A W
Title
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Citation
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed Id
First Author
Alenazi, Y
Title
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Citation
Scientific Reports; 8(1) pg6333
PubMed Id