Recombinant Human Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-27 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls. Calculated Molecular Weight: 16 kDa Accession Number: P41159 Gene ID: 3952 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Gaudino, S J Title Cutting Edge: Intestinal IL-17A Receptor Signaling Specifically Regulates High-Fat Diet-Mediated, Microbiota-Driven Metabolic Disorders. Citation Journal of immunology (Baltimore, Md. : 1950); 207(8) pg1959-1963 PubMed Id 34544802 First Author Deng, J Title The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses. Citation Nature Communications; 12(1) pg3073 PubMed Id 34031386 First Author Iqbal, J Title Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. Citation The Journal of Biological Chemistry; 295(13) pg4101-4113 PubMed Id 32047110
