Chemokine

Recombinant Human MCP-3 (CCL7)

Product Details

Catalogue Number: 300-17
Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-3 is a 9.0 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-3, CCL7, MARC

AA Sequence: QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 9 kDa

Accession Number: P80098

Gene ID: 6354

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Nardelli, B
Title
Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1.
Citation
Journal of immunology (Baltimore, Md. : 1950); 162(1) pg435-44
PubMed Id
First Author
Yanagihara, S
Title
EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(6) pg3096-102
PubMed Id
First Author
Bodaghi, B
Title
Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells.
Citation
The Journal of Experimental Medicine; 188(5) pg855-66
PubMed Id