Neurotrophine

Recombinant Human Midkine

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Product Details

Catalogue Number: 450-16
Description:
Recombinant Human Midkine

Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK).  MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development.  MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis.  Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

Source: E.coli

Synonyms: MK, NEGF-2

AA Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.

Calculated Molecular Weight: 13.4 kDa

Accession Number: P21741

Gene ID: 4192

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Cerezo-Wallis, D
Title
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Citation
Nature Medicine; 26(12) pg1865-1877
PubMed Id
First Author
Weckbach, L T
Title
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
Citation
The Journal of Experimental Medicine; 216(2) pg350-368
PubMed Id
First Author
Yu, Y
Title
Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics.
Citation
The Journal of Biological Chemistry; 290(29) pg17762-75
PubMed Id