Recombinant Human Midkine 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-16 Description: Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis. Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds. Source: E.coli Synonyms: MK, NEGF-2 AA Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml. Calculated Molecular Weight: 13.4 kDa Accession Number: P21741 Gene ID: 4192 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hagfish, Human, Mouse, Pig, Shark, Squid References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Cerezo-Wallis, D Title Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Citation Nature Medicine; 26(12) pg1865-1877 PubMed Id 33077955 First Author Weckbach, L T Title Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. Citation The Journal of Experimental Medicine; 216(2) pg350-368 PubMed Id 30647120 First Author Yu, Y Title Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics. Citation The Journal of Biological Chemistry; 290(29) pg17762-75 PubMed Id 26032414
