Recombinant Human MIF 0 BewertungenSubmit a Review Produktdetails Katalognummer: 300-69 Beschreibung: Macrophage migration inhibitory factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine, as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through CD74 and CD44, resulting in the secretion of TNF-a, IL-1, IL-6, IL-8, and various MMPs. The enzymatic activity of MIF is characterized by its ability to act as a tautomerase, capable of catalyzing the keto-to-enol isomerization of keto-phenylpyruvate and L-dopachrome. It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue. Insect cell-derived Recombinant Human MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag. Source: Hi-5 Insect cells Synonyms: Macrophage Migration Inhibitory Factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor AA Sequence: HHHHHHHHAM PMFIVNTNVP RASVPDGFLS ELTQQLAQAT GKPPQYIAVH VVPDQLMAFG GSSEPCALCS LHSIGKIGGA QNRSYSKLLC GLLAERLRIS PDRVYINYYD MNAANVGWNN STFA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit monocyte migration. Calculated Molecular Weight: 15 kDa Accession Number: P14174 Gene ID: 4282 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Inflammation product.subtitle.recentcitations Erstautor Cunningham, S Titel Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties. Literaturstelle Transfusion; 61(6) pg1845-1855 PubMed ID 33786883 Erstautor Zhang, L Titel Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Literaturstelle Cell; 181(2) pg442-459.e29 PubMed ID 32302573 Erstautor Stephenson, S Titel Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. Literaturstelle Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300 PubMed ID 30642980