Chemokine

Recombinant Human MIG (CXCL9)

Product Details

Catalogue Number: 300-26
Description:

MIG, a CXC chemokine, is produced by IFN-γ stimulated monocytes, macrophages and endothelial cells.  It signals through the CXCR3 receptor.  MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities, including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors.  Human MIG is active on murine cells.  Recombinant Human MIG is an 11.7 kDa protein containing 103 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: Monokine Induced by Interferon-gamma, CXCL9

AA Sequence: TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KTT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood T lymphocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 11.7 kDa

Accession Number: Q07325

Gene ID: 4283

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Cole, K E
Title
Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Citation
The Journal of Experimental Medicine; 187(12) pg2009-21
PubMed Id
First Author
Sallusto, F
Title
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Citation
The Journal of Experimental Medicine; 187(6) pg875-83
PubMed Id
First Author
Blanco-Melo, D
Title
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Citation
Cell; 181(5) pg1036-1045.e9
PubMed Id