Recombinant Human MIP-1α (CCL3) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-08 Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1α is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1α, CCL3, LD78α AA Sequence: ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P10147 Gene ID: 6348 crossreactivity: Bacteria, Cow, Frog, Hamster, Human, Human + Mouse, Human + Rat, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation product.subtitle.recentcitations First Author Bodaghi, B Title Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells. Citation The Journal of Experimental Medicine; 188(5) pg855-66 PubMed Id 9730887 First Author Tiffany, H L Title Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. Citation The Journal of Experimental Medicine; 186(1) pg165-70 PubMed Id 9207005 First Author Traer, E Title Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. Citation Blood; 123(10) pg1516-24 PubMed Id 24408322