Neurotrophine

Recombinant Human NT-3

Product Details

Catalogue Number: 450-03
Description:

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF

AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 27.2 kDa

Accession Number: P20783

Gene ID: 4908

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Vicario-Abejón, C
Title
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71
PubMed Id
First Author
Back, S A
Title
Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(16) pg6241-53
PubMed Id
First Author
Wang, S
Title
Notch receptor activation inhibits oligodendrocyte differentiation.
Citation
Neuron; 21(1) pg63-75
PubMed Id

product.subtitle.productreviews

Existing reviews
I have used PeproTech NT-3 since 2012
Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation!
From:  Louise | Date:  21.08.2020
Recombinant Human NT-3
This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality.
From:  Aala | Date:  26.08.2020