Recombinant Human NT-3 2 ReviewsSubmit a Review Product Details Catalogue Number: 450-03 Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Source: E.coli Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 27.2 kDa Accession Number: P20783 Gene ID: 4908 crossreactivity: Chicken, Cow, Dog, Frog, Hamster, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Vicario-Abejón, C Title Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. Citation The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71 PubMed Id 9736647 First Author Back, S A Title Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. Citation The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(16) pg6241-53 PubMed Id 9698317 First Author Wang, S Title Notch receptor activation inhibits oligodendrocyte differentiation. Citation Neuron; 21(1) pg63-75 PubMed Id 9697852 product.subtitle.productreviews Existing reviews I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 21.08.2020 × I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 21.08.2020 Close Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 26.08.2020 × Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 26.08.2020 Close
