Recombinant Human OPG 0 BewertungenSubmit a Review Produktdetails Katalognummer: 450-14 Beschreibung: Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues. Source: E.coli Synonyms: TNFRSF11B, Osteoprotegerin, OCIF (osteoclastogenesis inhibitory factor), TR1 AA Sequence: METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells. Calculated Molecular Weight: 20 kDa Accession Number: O00300 Gene ID: 4982 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cancer Immune System Receptors TNF Superfamily product.subtitle.recentcitations Erstautor Brito, H O Titel Immune-mediated febrile response in female rats: Role of central hypothalamic mediators. Literaturstelle Scientific Reports; 10(1) pg4073 PubMed ID 32139801 Erstautor Gooding, S Titel Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Literaturstelle Nature Communications; 10(1) pg4533 PubMed ID 31586071 Erstautor Ochiai, N Titel Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. Literaturstelle Communications Biology; 2 pg86 PubMed ID 30854478
